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91.
Journal of Natural Medicines - Investigations of antibacterial activities revealed that the incorporation of longer alkyl chains to the C-6 position in resorcylic acid conferred antibacterial... 相似文献
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Fujitani Kazumasa Kurokawa Yukinori Takeno Atsushi Kawabata Ryohei Omori Takeshi Imamura Hiroshi Hirao Motohiro Endo Shunji Kawada Junji Moon Jeong Ho Kobayashi Noboru Takahashi Tsuyoshi Yamasaki Makoto Takiguchi Shuji Mori Masaki Eguchi Hidetoshi Doki Yuichiro 《Annals of surgical oncology》2022,29(2):933-934
Annals of Surgical Oncology - 相似文献
93.
Kato Shunji Shiozaki Atsushi Kudou Michihiro Shimizu Hiroki Kosuga Toshiyuki Ohashi Takuma Arita Tomohiro Konishi Hirotaka Komatsu Shuhei Kubota Takeshi Fujiwara Hitoshi Okamoto Kazuma Kishimoto Mitsuo Konishi Eiichi Otsuji Eigo 《Annals of surgical oncology》2022,29(5):2944-2956
Annals of Surgical Oncology - Transient receptor potential vanilloid 2 (TRPV2) is a highly Ca2+-permeable ion channel that is involved in a number of cellular processes. It is expressed in various... 相似文献
94.
Kozaki Yohei Morinaga Takatoshi Fukatsu Atsushi Ito Takeshi Ishimoto Takuji Kosugi Tomoki Inaguma Daijo Tamai Hirofumi Maruyama Shoichi 《Clinical and experimental nephrology》2022,26(5):466-475
Clinical and Experimental Nephrology - A Dialysis Outcomes and Practice Patterns Study (DOPPS) has shown a one-to-one male-to-female mortality ratio, notwithstanding the statistically longer life... 相似文献
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Morikawa Takanori Ishida Masaharu Takadate Tatsuyuki Hata Tatsuo Iseki Masahiro Kawaguchi Kei Ohtsuka Hideo Mizuma Masamichi Hayashi Hiroki Nakagawa Kei Motoi Fuyuhiko Kamei Takashi Naitoh Takeshi Unno Michiaki 《Surgery today》2020,50(2):153-162
Surgery Today - We introduced a superior approach and a unique technique to retract the stomach, called the “stomach roll-up technique”, to standardize laparoscopic distal... 相似文献
97.
Hiroaki Onuma Kunikazu Tsuji Takashi Hoshino Kei Inomata Mio Udo Yusuke Nakagawa Hiroki Katagiri Kazumasa Miyatake Toshifumi Watanabe Ichiro Sekiya Takeshi Muneta Hideyuki Koga 《Journal of orthopaedic research》2020,38(6):1296-1306
The infrapatellar fat pad (IFP) contains nerve fiber endings and is considered to play an important role in the perception of knee pain. However, it is unclear whether and to what degree prolonged pain influences the nociceptive role of the IFP. To answer this question, we established a novel rat model of knee pain in which inflammation is restricted to the IFP. Rats received a single intra-IFP injection of monoiodoacetic acid (MIA) (0.2 mg/10 µL or 1.0 mg/10 µL) in the left knee and a phosphate-buffered saline (10 µL) injection in the right knee as a control. Pain-avoidance behavior and histological changes of the knee joint were measured at multiple time points up to 28 days after MIA injection. Histological analysis showed a transient inflammatory response in the IFP body in the 0.2-mg model, whereas prolonged inflammation followed by fibrotic changes was observed in the 1.0-mg model. Subtle histological alterations were observed in the articular cartilage and IFP surface regardless of the dose. The pain-avoidance behavior test indicated the development of prolonged knee pain throughout the experimental period in the 1.0-mg group. Histological assessments showed a significant increase in calcitonin gene-related peptide (CGRP)-positive nerve fiber endings inside IFPs with fibrosis in newly vascularized surrounding regions. These data suggest that irreversible fibrotic changes in the IFP induce the formation of new vessels and CGRP-positive nerve fiber endings that associate prolonged pain in the joint. 相似文献
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JMJD2B/KDM4B inactivation in adipose tissues accelerates obesity and systemic metabolic abnormalities 下载免费PDF全文
Changkeun Kang Kayoko Saso Kazushige Ota Masahito Kawazu Takeshi Ueda Hitoshi Okada 《Genes to cells : devoted to molecular & cellular mechanisms》2018,23(9):767-777
Obesity is a serious global health issue; however, the roles of genetics and epigenetics in the onset and progression of obesity are still not completely understood. The aim of this study was to determine the role of Kdm4b, which belongs to a subfamily of histone demethylases, in adipogenesis and fat metabolism in vivo. We established conditional Kdm4b knockout mice. Inactivation of Kdm4b in adipocytes (K4bKO) induced profound obesity in mice on a high fat diet (HFD). The HFD‐fed K4bKO mice exhibited an increased volume of fat mass and higher expression levels of adipogenesis‐related genes. In contrast, the genes involved in energy expenditure and mitochondrial functions were down‐regulated. Supporting these findings, the energy expenditure of Kdm4b‐deficient cells was markedly decreased. In addition, progression of glucose intolerance and hepatic steatosis with hepatocellular damages was observed. These data indicate that Kdm4b is a critical regulator of systemic metabolism via enhancing energy expenditure in adipocytes. 相似文献